Scientists_Discover_Immune_Cells_Worsening_Chronic_Sinusitis

Scientists Discover Immune Cells Worsening Chronic Sinusitis

A groundbreaking study published in the prestigious Nature journal has unveiled that a specific type of immune cell, once thought to be a crucial defender, is actually exacerbating persistent inflammation and tissue damage in chronic sinusitis and nasal polyps.

After nearly a decade of meticulous research, scientists from China's Tsinghua University and Beijing Tongren Hospital have identified Granzyme K (GZMK), a protein secreted by a specialized type of memory CD8+ T cell, as the key culprit behind the chronic condition.

"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces," explained Dr. Zhang Luo from Beijing Tongren Hospital. "Among them, memory CD8+ T cells are like specialized commandos."

"Unlike traditional cells that release Granzyme B, these cells secrete Granzyme K, which bypasses the need for antibodies to activate the body's defense system. However, instead of protecting, Granzyme K intensifies tissue damage and inflammation, worsening the condition," he added.

Chronic sinusitis and nasal polyps affect millions worldwide, causing symptoms like nasal congestion, loss of smell, and headaches. While current treatments offer temporary relief, many patients experience recurrent episodes, underscoring the need for more effective therapies.

The study suggests that GZMK is a promising new drug target. Experimental models demonstrated that inhibiting GZMK significantly reduced inflammation.

"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence," said Professor Qi Hai of Tsinghua University. "This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases."

The findings offer new hope for patients suffering from chronic sinus conditions, pointing toward more effective, targeted treatments that address the underlying causes rather than just the symptoms.

(Reporting by Gong Zhe)

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