A groundbreaking study published in the prestigious journal Nature has unveiled that a specific type of immune cell, once considered a vital defender, may actually exacerbate chronic sinus infections and nasal polyps. This revelation comes after nearly a decade of meticulous research by scientists from China's Tsinghua University and Beijing Tongren Hospital.
The team identified Granzyme K (GZMK), a protein secreted by a specialized type of memory CD8+ T cell, as a key factor in fueling persistent inflammation and tissue damage in chronic sinusitis. \"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos.\"
Dr. Zhang noted that unlike traditional cells that release Granzyme B, these specialized cells secrete Granzyme K, which bypasses the need for antibodies to activate the body's defense system. \"However, instead of protecting, Granzyme K intensifies tissue damage and inflammation, worsening the condition,\" he said.
Chronic sinusitis and nasal polyps affect millions worldwide, causing symptoms such as nasal congestion, loss of smell, and headaches. While current treatments offer temporary relief, many patients experience recurrent episodes, highlighting the need for more effective therapies.
The study suggests that GZMK could be a promising new drug target. Experimental models demonstrated that inhibiting GZMK significantly reduced inflammation. \"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
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Scientists find immune cells fueling chronic sinus infections
cgtn.com
