Scientists have made a groundbreaking discovery that could revolutionize the treatment of chronic sinusitis and nasal polyps.
A new study published in the prestigious journal Nature has revealed that a specific type of immune cell, previously considered a vital defender, can actually fuel persistent inflammation and tissue damage in these conditions.
After nearly a decade of investigation, researchers from China's Tsinghua University and Beijing Tongren Hospital have identified Granzyme K (GZMK), a protein secreted by a specialized type of memory CD8+ T cell, as the key culprit behind the persistent inflammation.
\"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos.\"
\"Unlike traditional cells that release Granzyme B, these cells secrete Granzyme K, which bypasses the need for antibodies to activate the body's defense system. However, instead of protecting, Granzyme K intensifies tissue damage and inflammation, worsening the condition,\" Dr. Zhang added.
Chronic sinusitis and nasal polyps affect millions worldwide, causing symptoms like nasal congestion, loss of smell, and headaches. While current treatments offer temporary relief, many patients experience recurrent episodes.
The study suggests GZMK as a promising new drug target. Experimental models demonstrated that inhibiting GZMK significantly reduced inflammation.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence, potentially revolutionizing the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases,\" said Professor Qi Hai of Tsinghua University.
This discovery offers hope for the millions suffering from these chronic conditions, paving the way for more effective treatments that address the root cause rather than just managing symptoms.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
