Scientists in China have uncovered a surprising culprit behind chronic sinusitis and nasal polyps: a specific type of immune cell that intensifies inflammation and tissue damage.
After nearly a decade of research, teams from Tsinghua University and Beijing Tongren Hospital have identified Granzyme K (GZMK), a protein secreted by a specialized memory CD8+ T cell, as the key factor exacerbating these chronic conditions.
\"White blood cells are like the body's defense army, with T lymphocytes serving as the elite forces,\" explained Dr. Zhang Luo of Beijing Tongren Hospital. \"These specialized memory CD8+ T cells are akin to commandos. Unlike traditional cells that release Granzyme B, these cells secrete Granzyme K, which can activate the body's defense system without antibodies. However, instead of protecting, Granzyme K worsens tissue damage and inflammation.\"
Chronic sinusitis and nasal polyps affect millions worldwide, leading to symptoms such as nasal congestion, loss of smell, and headaches. Current treatments often provide only temporary relief, with many patients experiencing recurrent episodes.
The discovery of GZMK's role offers a promising new target for drug development. Experimental models showed that inhibiting GZMK significantly reduced inflammation.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment of chronic sinusitis, nasal polyps, and related allergic diseases.\"
The study, published in the journal Nature, opens new avenues for understanding and treating chronic inflammatory diseases, offering hope to millions suffering from these persistent conditions.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
