A groundbreaking study published in the prestigious journal Nature has unveiled that certain immune cells, once thought to be defenders, are actually exacerbating chronic sinus infections. Researchers from China\u0027s Tsinghua University and Beijing Tongren Hospital have identified a protein called Granzyme K (GZMK) as the key factor fueling persistent inflammation and tissue damage in patients with chronic sinusitis and nasal polyps.
\"White blood cells can be seen as the body\u0027s defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo of Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos.\"
These specialized immune cells, instead of secreting the conventional Granzyme B, release Granzyme K. This protein, while intended to activate the body\u0027s defense without the need for antibodies, ends up intensifying tissue damage and inflammation.
Chronic sinusitis and nasal polyps affect millions globally, leading to symptoms such as nasal congestion, loss of smell, and headaches. Current treatments often provide only temporary relief, with many patients experiencing recurrent episodes.
The discovery of GZMK\u0027s role opens new avenues for treatment. Experimental models demonstrated that inhibiting GZMK significantly reduces inflammation. \"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
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Scientists find immune cells fueling chronic sinus infections
cgtn.com
