In a groundbreaking study published in the scientific journal Nature, researchers from Tsinghua University and Beijing Tongren Hospital have discovered that a specific type of immune cell, previously thought to be a key defender in the body, can actually exacerbate chronic sinusitis and nasal polyps.
After nearly a decade of investigation, the team identified Granzyme K (GZMK), a protein secreted by a specialized type of memory CD8+ T cell, as the primary contributor to persistent inflammation and tissue damage in these conditions.
\"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo of Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos.\"
Dr. Zhang noted that unlike traditional cells that release Granzyme B, these particular cells secrete Granzyme K. \"Granzyme K bypasses the need for antibodies to activate the body's defense system. However, instead of protecting, it intensifies tissue damage and inflammation, worsening the condition.\"
Chronic sinusitis and nasal polyps affect millions worldwide, causing symptoms such as nasal congestion, loss of smell, and headaches. While current treatments offer temporary relief, many patients experience recurrent episodes, highlighting the need for more effective therapies.
The study's findings suggest that GZMK could be a promising new drug target. Experimental models demonstrated that inhibiting GZMK significantly reduced inflammation, paving the way for potential new treatments.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
