In a significant breakthrough, scientists from China's Tsinghua University and Beijing Tongren Hospital have identified a specific type of immune cell that exacerbates inflammation in chronic sinusitis and nasal polyps. Published in the journal Nature, the study reveals that these immune cells, previously considered essential defenders, are contributing to persistent inflammation and tissue damage in patients worldwide.
\"White blood cells are like the body's defense army, with T lymphocytes acting as elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells function as specialized commandos.\"
The researchers discovered that a protein called Granzyme K (GZMK), secreted by these memory CD8+ T cells, plays a pivotal role in intensifying inflammation. Unlike traditional cells that release Granzyme B to combat pathogens, these cells release Granzyme K, which bypasses the need for antibodies. However, instead of safeguarding the body, Granzyme K amplifies tissue damage and inflammation, worsening chronic sinus conditions.
Chronic sinusitis and nasal polyps affect millions of people globally, leading to symptoms such as nasal congestion, loss of smell, and headaches. Current treatments often provide only temporary relief, with many patients experiencing recurrent episodes.
The identification of Granzyme K as a key contributor opens new avenues for therapeutic interventions. Experimental models showed that inhibiting GZMK significantly reduced inflammation, suggesting it as a promising drug target.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for chronic sinusitis, nasal polyps, and related allergic diseases.\"
The study offers hope for more effective treatments, aiming to improve the quality of life for those suffering from these chronic conditions.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
