Scientists in China have uncovered a specific type of immune cell that exacerbates chronic sinusitis and nasal polyps, potentially paving the way for new treatments for millions suffering worldwide.
In a study published in the journal Nature, researchers from Tsinghua University and Beijing Tongren Hospital spent nearly a decade investigating the role of Granzyme K (GZMK), a protein secreted by a specialized type of memory CD8+ T cell.
\"White blood cells are the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos.\"
Unlike traditional cells that release Granzyme B, these cells secrete Granzyme K, which bypasses the need for antibodies to activate the body's defense system. However, instead of protecting, Granzyme K intensifies tissue damage and inflammation, worsening the condition.
Chronic sinusitis and nasal polyps affect millions worldwide, causing symptoms like nasal congestion, loss of smell, and headaches. While current treatments offer temporary relief, many patients experience recurrent episodes.
The study suggests that GZMK could be a promising new drug target. Experimental models demonstrated that inhibiting GZMK significantly reduced inflammation.
'In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence, potentially revolutionizing the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases,' said Professor Qi Hai of Tsinghua University.
This discovery not only enhances the understanding of chronic sinusitis but also opens doors to more effective therapies, offering hope to patients who have long struggled with the ailment.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
