In a groundbreaking discovery, scientists from China's Tsinghua University and Beijing Tongren Hospital have identified a specific type of immune cell that exacerbates chronic sinus infections and nasal polyps. Published in the journal Nature, the study reveals that these cells, previously thought to be vital defenders, are fueling persistent inflammation and tissue damage.
\"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos.\"
The researchers found that these memory CD8+ T cells secrete Granzyme K (GZMK), a protein that intensifies tissue damage and inflammation without the need for antibodies. \"Unlike traditional cells that release Granzyme B, these cells secrete Granzyme K, which, instead of protecting, worsens the condition,\" Dr. Zhang added.
Chronic sinusitis and nasal polyps affect millions worldwide, causing symptoms such as nasal congestion, loss of smell, and headaches. While current treatments offer temporary relief, many patients experience recurrent episodes.
The study suggests that GZMK could be a promising new drug target. Experimental models showed that inhibiting GZMK significantly reduced inflammation. \"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
The discovery not only sheds light on the underlying mechanisms of these chronic conditions but also opens new avenues for therapeutic interventions. By targeting the very cells that contribute to the problem, treatments could become more effective and long-lasting.
(Reporting by Gong Zhe)
Reference(s):
Scientists find immune cells fueling chronic sinus infections
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