Beijing, China — A groundbreaking study published in the prestigious journal Nature has revealed that a specific type of immune cell, previously considered a vital defender, is actually fueling persistent inflammation and tissue damage in chronic sinusitis and nasal polyps.
After nearly a decade of meticulous research, scientists from the Chinese mainland's Tsinghua University and Beijing Tongren Hospital have identified Granzyme K (GZMK), a protein secreted by a specialized type of memory CD8+ T cell, as the key culprit behind the stubborn nature of these conditions.
\"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos. Unlike traditional cells that release Granzyme B, these cells secrete Granzyme K, which bypasses the need for antibodies to activate the body's defense system. However, instead of protecting, Granzyme K intensifies tissue damage and inflammation, worsening the condition.\"
Chronic sinusitis and nasal polyps affect millions worldwide, leading to symptoms like nasal congestion, loss of smell, and headaches. While current treatments offer temporary relief, many patients experience recurrent episodes that significantly impact their quality of life.
The discovery of GZMK's role opens new avenues for treatment. Experimental models demonstrated that inhibiting Granzyme K significantly reduced inflammation, suggesting it as a promising new drug target.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
The research team's findings not only deepen the understanding of immune system mechanisms but also offer hope to patients suffering from chronic respiratory conditions.
(Reporting by Gong Zhe)
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
