In a groundbreaking study published in the scientific journal Nature, researchers from Tsinghua University and Beijing Tongren Hospital have unearthed a surprising contributor to chronic sinusitis and nasal polyps: a specific type of immune cell previously thought to be a defender.
After nearly a decade of meticulous investigation, the team identified Granzyme K (GZMK), a protein secreted by a specialized form of memory CD8+ T cells, as the key culprit behind persistent inflammation and tissue damage in patients suffering from these chronic conditions.
\"White blood cells are like the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo of Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are akin to specialized commandos.\"
What makes these cells unique is their secretion of Granzyme K, rather than the traditional Granzyme B. \"Granzyme K bypasses the need for antibodies to activate the body's defense system,\" Dr. Zhang noted. \"However, instead of protecting the body, Granzyme K intensifies tissue damage and inflammation, worsening the condition.\"
Chronic sinusitis and nasal polyps affect millions worldwide, leading to symptoms such as nasal congestion, loss of smell, and headaches. Current treatments often provide only temporary relief, with many patients experiencing recurrent episodes that significantly impact their quality of life.
The discovery of GZMK's role opens new avenues for treatment. Experimental models demonstrated that inhibiting GZMK significantly reduced inflammation. \"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
The study's findings not only shed light on the underlying mechanisms of these chronic conditions but also offer hope for more effective therapies. By targeting the very cells that exacerbate inflammation, new treatments may provide lasting relief for patients worldwide.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
