A team of Chinese scientists from Tsinghua University and Beijing Tongren Hospital has uncovered a surprising culprit behind chronic sinusitis and nasal polyps—a specialized type of immune cell that exacerbates inflammation and tissue damage.
Published in the scientific journal Nature, the study reveals that Granzyme K (GZMK), a protein secreted by a unique subset of memory CD8+ T cells, plays a critical role in fueling persistent inflammation. These findings challenge previous beliefs about the protective role of these immune cells.
\"White blood cells are the body's defense army, with T lymphocytes acting as elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos. However, instead of safeguarding the body, those secreting Granzyme K intensify tissue damage and inflammation, worsening the condition.\"
Chronic sinusitis and nasal polyps affect millions worldwide, leading to symptoms such as nasal congestion, loss of smell, and headaches. Current treatments often provide only temporary relief, and many patients experience recurrent episodes.
The identification of GZMK as a key factor opens new avenues for treatment. Experimental models demonstrated that inhibiting GZMK significantly reduced inflammation, suggesting that it could be a promising drug target.
\"Medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This discovery has the potential to revolutionize the treatment of chronic sinusitis, nasal polyps, and related allergic diseases.\"
This breakthrough not only enhances the understanding of chronic inflammatory diseases but also offers hope for developing more effective therapies, improving the quality of life for countless individuals globally.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
