A team of Chinese scientists has uncovered a surprising culprit behind chronic sinus infections and nasal polyps\u2014a specific type of immune cell previously thought to be a defender against disease.
Published in the prestigious journal Nature, the study by researchers from Tsinghua University and Beijing Tongren Hospital reveals that memory CD8+ T cells secrete a protein called Granzyme K (GZMK), which intensifies inflammation and tissue damage in chronic sinusitis.
\"White blood cells are like the body's defense army, with T lymphocytes as its elite forces,\" explained Dr. Zhang Luo of Beijing Tongren Hospital. \"Among them, memory CD8+ T cells act like specialized commandos.\"
Dr. Zhang noted that unlike traditional cells that release Granzyme B, these memory CD8+ T cells secrete Granzyme K. \"This protein bypasses the need for antibodies to activate the body's defense system. However, instead of protecting, Granzyme K exacerbates tissue damage and inflammation, worsening the condition.\"
Chronic sinusitis and nasal polyps affect millions globally, leading to symptoms such as nasal congestion, loss of smell, and headaches. While current treatments provide temporary relief, many patients suffer from recurring episodes.
The identification of GZMK as a key factor in this persistent inflammation opens new avenues for treatment. Experimental models demonstrated that inhibiting GZMK significantly reduced inflammation.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This discovery has the potential to revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
The findings offer hope for more effective therapies, aiming to improve the quality of life for those affected by these chronic conditions.
\u2014 Reporting by Gong Zhe
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
