Scientists Discover Immune Cell Behind Chronic Sinus Infections
A groundbreaking study by researchers from China's Tsinghua University and Beijing Tongren Hospital has identified a specific type of immune cell that exacerbates chronic sinusitis and nasal polyps, conditions affecting millions worldwide.
Published recently in the journal Nature, the study reveals that Granzyme K (GZMK), a protein secreted by a specialized memory CD8+ T cell, intensifies inflammation and tissue damage, rather than defending the body as previously believed.
\"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos. Unlike traditional cells that release Granzyme B, these cells secrete Granzyme K, which bypasses the need for antibodies to activate the body's defense system. However, instead of protecting, Granzyme K intensifies tissue damage and inflammation, worsening the condition.\"
Chronic sinusitis and nasal polyps lead to symptoms such as nasal congestion, loss of smell, and headaches. Current treatments often provide only temporary relief, with many patients experiencing recurrent episodes.
After nearly a decade of investigation, the research team pinpointed GZMK as a promising new target for drug development. Experimental models demonstrated that inhibiting GZMK significantly reduced inflammation, opening the door to more effective therapies.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
The discovery offers hope for millions suffering from chronic sinus conditions, presenting a potential pathway to longer-lasting relief and improved quality of life.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
