A groundbreaking study published in the scientific journal Nature has unveiled that a specific type of immune cell, once considered a crucial defender, actually contributes to persistent inflammation and tissue damage in chronic sinusitis and nasal polyps.
After nearly a decade of meticulous research, scientists from China's Tsinghua University and Beijing Tongren Hospital have pinpointed Granzyme K (GZMK), a protein secreted by a specialized form of memory CD8+ T cells, as the key culprit behind the condition's aggravation.
\"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos.\"
Dr. Zhang elaborated that unlike traditional cells releasing Granzyme B, these particular cells secrete Granzyme K. \"This protein bypasses the need for antibodies to activate the body's defense system. However, instead of safeguarding the body, Granzyme K intensifies tissue damage and inflammation, worsening the condition,\" he noted.
Chronic sinusitis and nasal polyps affect millions globally, leading to symptoms such as nasal congestion, loss of smell, and headaches. While existing treatments offer temporary relief, many patients experience recurrent episodes that diminish their quality of life.
The discovery of GZMK's role offers a promising new target for drug development. Experimental models showcased that inhibiting GZMK significantly reduced inflammation, pointing toward more effective interventions.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
The findings not only deepen the understanding of immune system functions but also open doors to innovative therapies that may alleviate suffering for countless individuals worldwide.
Gong Zhe contributed to this story.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
