A groundbreaking study published in the journal Nature reveals that a specific type of immune cell, once considered a vital defender, is actually contributing to persistent inflammation and tissue damage in chronic sinusitis and nasal polyps.
After nearly a decade of research, scientists from China's Tsinghua University and Beijing Tongren Hospital have identified Granzyme K (GZMK), a protein secreted by a specialized type of memory CD8+ T cell, as the key culprit behind these chronic conditions.
\"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos. Unlike traditional cells that release Granzyme B, these cells secrete Granzyme K, which bypasses the need for antibodies to activate the body's defense system. However, instead of protecting, Granzyme K intensifies tissue damage and inflammation, worsening the condition.\"
Chronic sinusitis and nasal polyps affect millions worldwide, leading to symptoms such as nasal congestion, loss of smell, and headaches. Current treatments often provide only temporary relief, with many patients experiencing recurrent episodes.
The study suggests that GZMK is a promising new drug target. Experimental models demonstrated that inhibiting Granzyme K significantly reduces inflammation, offering hope for more effective treatments.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
(Gong Zhe contributed to this story.)
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
