In a breakthrough that could revolutionize treatments for chronic sinusitis and nasal polyps, scientists from China's Tsinghua University and Beijing Tongren Hospital have identified a specific immune cell that exacerbates inflammation and tissue damage.
Published in the prestigious journal Nature, the study reveals that Granzyme K (GZMK), a protein secreted by a specialized type of memory CD8+ T cell, plays a key role in fueling persistent inflammation. This discovery challenges previous assumptions about these immune cells, which were once considered vital defenders against disease.
\"White blood cells are like the body's defense army, with T lymphocytes serving as elite forces,\" explained Dr. Zhang Luo of Beijing Tongren Hospital. \"Among them, memory CD8+ T cells function as specialized commandos. However, instead of protecting, those secreting Granzyme K intensify tissue damage and inflammation, worsening the condition.\"
Chronic sinusitis and nasal polyps affect millions globally, leading to symptoms such as nasal congestion, loss of smell, and headaches. Current treatments often provide only temporary relief, with many patients experiencing recurrent episodes.
The identification of GZMK as a culprit offers new hope. Experimental models demonstrated that inhibiting Granzyme K significantly reduces inflammation, pointing to the protein as a promising drug target.
\"Medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially transform the treatment landscape for chronic sinusitis, nasal polyps, and related allergic diseases.\"
The research team hopes that their findings will pave the way for more effective therapies, improving quality of life for those suffering from these chronic conditions.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
