Scientists from China\u0027s Tsinghua University and Beijing Tongren Hospital have uncovered a surprising culprit behind chronic sinus infections and nasal polyps\u2014a specific type of immune cell previously considered a vital defender. Their decade-long research, published in the journal Nature, reveals that a protein called Granzyme K (GZMK), secreted by specialized memory CD8+ T cells, intensifies inflammation and tissue damage rather than protecting against it.
\\"Think of white blood cells as the body\u0027s defense army, with T lymphocytes as its elite forces,\\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \\"Among them, memory CD8+ T cells are like specialized commandos. However, these 'commandos' are releasing Granzyme K instead of the usual Granzyme B, which bypasses the need for antibodies but ends up worsening inflammation.\\"
Chronic sinusitis and nasal polyps affect millions worldwide, leading to symptoms such as nasal congestion, loss of smell, and headaches. Current treatments often provide only temporary relief, with many patients experiencing recurrent episodes.
The discovery of GZMK\u0027s role offers new hope for sufferers. Experimental models showed that inhibiting GZMK significantly reduced inflammation, suggesting that Granzyme K could be a promising target for new therapies.
\\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\\" said Professor Qi Hai of Tsinghua University. \\"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\\"
The findings open avenues for developing more effective treatments, offering long-term relief to those affected by these persistent conditions.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
