Scientists Identify Key Immune Cell Driving Chronic Sinusitis
In a groundbreaking study published in the prestigious journal Nature, researchers from China's Tsinghua University and Beijing Tongren Hospital have unveiled a surprising culprit behind chronic sinus infections and nasal polyps. The team discovered that a specific type of immune cell, previously deemed a vital defender, is actually fueling persistent inflammation and tissue damage.
After nearly a decade of meticulous investigation, the scientists pinpointed Granzyme K (GZMK), a protein secreted by a specialized type of memory CD8+ T cell, as the key offender. This protein, instead of safeguarding the body, intensifies inflammation and exacerbates tissue damage in the nasal passages.
\"White blood cells can be seen as the body's defense army, with T lymphocytes serving as its elite forces,\" explained Dr. Zhang Luo from Beijing Tongren Hospital. \"Among them, memory CD8+ T cells are like specialized commandos. Unlike traditional cells that release Granzyme B, these cells secrete Granzyme K, which bypasses the need for antibodies to activate the body's defense system. However, instead of protecting, Granzyme K intensifies tissue damage and inflammation, worsening the condition.\"
Chronic sinusitis and nasal polyps affect millions worldwide, causing symptoms like nasal congestion, loss of smell, and headaches. Despite current treatments offering temporary relief, many patients experience recurrent episodes that impact their quality of life.
The discovery of GZMK's role opens new avenues for treatment. Experimental models showed that inhibiting Granzyme K significantly reduced inflammation, suggesting it as a promising new drug target.
\"In the future, medications designed to target Granzyme K could help control inflammation and reduce recurrence,\" said Professor Qi Hai of Tsinghua University. \"This could potentially revolutionize the treatment landscape for conditions like chronic sinusitis, nasal polyps, and related allergic diseases.\"
This breakthrough not only enhances the understanding of immune mechanisms in chronic sinus conditions but also offers hope for more effective therapies, benefiting millions of sufferers worldwide.
Reference(s):
Scientists find immune cells fueling chronic sinus infections
cgtn.com
