Chinese Researchers Achieve Breakthrough in Gene-Edited Pig Kidney Transplant
In a significant medical advancement, Chinese researchers have successfully transplanted a genetically modified pig kidney into a brain-dead human recipient, with the organ functioning effectively for nine days. This achievement marks a critical step forward in the field of xenotransplantation and offers renewed hope for addressing the global shortage of donor organs.
The transplant surgery was performed on March 25 by a medical team led by Dr. Qin Weijun at Xijing Hospital of the Air Force Medical University in Xi’an, Shaanxi Province. The procedure was guided by Dou Kefeng, an academician from the Chinese Academy of Sciences. Over the course of a meticulous 6-hour and 15-minute operation, the team implanted the gene-edited pig kidney into the recipient’s right iliac fossa.
“After we removed the vessel-blocking clamp, the transplanted kidney showed excellent perfusion and began producing urine immediately,” Dr. Qin reported. “Intraoperative ultrasound confirmed good blood flow within the organ, indicating that no hyperacute rejection occurred.”
The surgical plan underwent rigorous review and approval by various academic and ethics committees, ensuring compliance with national regulations. The family of the brain-dead patient consented to the procedure, expressing a desire to contribute to medical advancement.
Dr. Qin emphasized the significance of this breakthrough: “With the rapid development of gene editing technology and immunology, xenotransplantation research has made dramatic progress in recent years. This successful transplant may become an effective way to solve the shortage of organs in the future.”
This accomplishment follows a similar feat earlier in the month. On March 10, the same hospital successfully transplanted a genetically modified pig liver into a brain-dead person. The liver functioned for ten days before the study concluded, as per the family’s wishes.
These pioneering efforts by Chinese medical experts highlight the potential of xenotransplantation to revolutionize organ transplantation. For patients with end-stage organ diseases, such advancements could offer new avenues for treatment and improved quality of life.
Reference(s):
Chinese researchers transplant gene-edited pig kidney into human body
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