Australian researchers have identified measurable biological abnormalities in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), challenging historical perceptions of the condition as psychological. A Macquarie University-led study published in Cell Reports Medicine reveals systemic changes across immune function, cellular energy production, and vascular health markers.
Key Biological Markers Identified
The research team analyzed blood samples from 61 ME/CFS patients and healthy controls, finding:
Impaired cellular energy production with reduced ATP generation
Immature immune cell profiles affecting T-lymphocytes and natural killer cells
Senior author Dr. Richard Schloeffel noted the discovery of seven biological variables strongly associated with ME/CFS could revolutionize diagnosis: "This model may reduce diagnostic delays that currently average 3-5 years, potentially alleviating the $20 billion annual economic burden from lost productivity."
The findings come as Asian healthcare systems increasingly recognize ME/CFS, with Japan and South Korea reporting rising diagnosis rates following improved medical education about the condition.
